Any tissue will do the job. But when you are sick or grieving and you are going through them for weeks on end, you notice the difference between Puffs and every other brand. There is a HUGE difference. These tissues don't fall apart and crumble all over you face like others do. Yet, they are exponentially softer than all the others. I hope you never have to find out the difference. But if you do, you will agree. Puffs are the BAR NONE best!